IBIS Tamoxifen placebo Breast cancer High risk premenopausal and postmenopausal women 8000 CORE Raloxifene placebo Osteoporosis extension of MORE High risk postmenopausal women 7500 approximately closed RUTH Raloxifene placebo Coronary heart disease High risk postmenopausal women 10 000 closed STAR Raloxifene or tamoxifen Breast cancer High risk postmenopaus